Botox can be used as an off-label (non-FDA approved) treatment for Hidradenitis Suppurativa (HS), and it is most beneficial for those with stages 1 and 2. Botox may also be beneficial for those with stage 3 HS if only a few areas are affected.
If you suffer from excessive sweating, which can be a trigger for some, Botox may be helpful. However, Botox cannot be used over large areas of the body, and you can’t receive multiple injections at the same time, as this could be too toxic. To treat multiple areas, or a more severe region, the procedure must be done one area at a time. Botox is not a cure and would require lifelong treatment. Depending on the severity of your condition, maintenance treatment might be needed approximately every six months for each area.
Botulinum toxin (Botox) is a neurotoxin produced by the bacterium Clostridium botulinum, which causes flaccid muscle paralysis. It is used off-label to treat hyperhidrosis (chronic sweating). Botulinum toxin works by inhibiting the release of acetylcholine at postganglionic cholinergic synapses, which reduces sympathetic activation of sweat glands. In HS, it is proposed that the subsequent decrease in apocrine gland activity limits the tendency for follicular rupture and inflammation. Further research is needed to understand the role of Botox use for Hidradenitis Suppurativa management, including optimal dosage and frequency of administration.
Possible Side Effects of Botox
Botox does come with potential side effects. Keep in mind that not everyone will experience these side effects. The side effects listed below are more common when Botox is used in lymph node areas, especially with frequent use. As with any pharmaceutical drug, it's important to weigh the risks and benefits.
Most common side effects include:
● Dizziness
● Difficulty swallowing
● Respiratory infections (such as cold or flu)
● Pain
● Nausea
● Headache
● Muscle weakness
● Double vision
● Drooping or swollen eyelids
● Eye irritation, dry eyes, tearing, reduced blinking
● Increased sensitivity to light
● Fever
● Neck or back pain
● Anxiety
A very serious allergic reaction to this drug is rare, but if you notice any symptoms of a serious allergic reaction—such as itching/swelling (especially of the face/tongue/throat), rash, severe dizziness, or trouble breathing—seek medical help immediately.
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