Subject: Inflammatory, Systemic & Follicle

Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support ​ https://www.ncbi.nlm.nih.gov/m/pubmed/23320858

https://www.jidonline.org/article/S0022-202X(16)31247-7/fulltext

Synopsis: Background: Despite the heavy purulence observed in hidradenitis suppurativa (HS), the kinetics of complement anaphylatoxins acting to prime chemotaxis of neutrophils has not been studied. Objectives: To explore complement activation in HS. Methods: Circulating concentrations of complement factor C5a, as well as of membrane attack complex C5b-9, were determined in the plasma of 54 […]

Synopsis: A rather long, yet interesting Oxford Article link is below which explains auto-inflammatory disorders and the innate immune. Hidradenitis suppurativa (HS) has long been considered an anatomical disorder of apocrine sweat glands or an immunodeficiency. More recently it has become clear that it behaves as an auto-inflammatory disorder. The auto-inflammatory syndromes represent an expanding […]

Synopsis: In this review, we collected all the information concerning the OMICs studies performed on HS patients aimed at unraveling the mechanisms at the basis of the disease or associated to clinical severity and/or the successful response to pharmacological treatment (including biological drugs). The general picture of the OMICs contribution in the context of HS […]

A total of 32 eligible publications were identified by the systematic search; these were supplemented with three additional publications. The extracted data indicated that four key themes underlie the pathogenesis of HS . Based on recent data, an integrative viewpoint is presented on the pathogenesis of HS. Current evidence highlights a complex multifactorial pathogenesis (5). […]

Synopsis of Research: Etiology Auto-inflammatory Many previously accepted models of HS pathogenesis are being challenged. It is now believed that HS is a systemic inflammatory disease of multifactorial basis, possibly due to auto-inflammation 53. It was formerly hypothesized that the disease originated in apocrine-bearing locations of the body, such as the groin and anogenital and […]

Synopsis: Implicating the immune system in hidradenitis suppurativa The cause of the painful skin condition hidradenitis suppurativa (acne inversa) is unknown. To better understand pathogenesis of this debilitating disease, Byrd et al. examined blood and lesional skin of patients and healthy controls. They observed prominent neutrophil extracellular traps (NETs), plasma cells, autoantibodies, and a type […]

Synopsis: In this study, we observed an increased frequency of functional CD4+ T cells secreting IL-17 or IL-22 in the blood of patients with HS compared with healthy donors (HD). However, we did not observe an increased frequency of infiltrating CD4+ T cells secreting IL-22 in HS skin lesions, but we found an increased frequency […]

Is Mechanical Stress an Important Pathogenic Factor in Hidradenitis Suppurativa?​ Synopsis: In summary, we present a patient with inflammatory lesions, resembling HS, at an ectopic location free of apocrine sweat glands and probably induced by a leg prosthesis. We argue that predilection sites of HS are not characterized by the presence of apocrine sweat glands […]