Bacterial biofilm in chronic lesions of hidradenitis suppurativa Synopsis: Background: Chronic nonhealing or recurrent inflammatory lesions, reminiscent of infection but recalcitrant to antibiotic therapy, generally characterize biofilm-driven diseases. Chronic lesions […]
Subject: Hormone, Gene & Microbiome
Cutaneous Microbiome: Light at the End of the Microbiological Tunnel
The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa Light at the End of the Microbiological Tunnel Synopsis: Hidradenitis suppurativa is a chronic, debilitating inflammatory skin disease whose pathophysiology […]
Alterations in Innate Immunity & Epithelial Cell Differentiation
Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa Synopsis: Alterations to key regulatory pathways involving glucocorticoid receptor, atherosclerosis, HIF1α and IL17A signalling […]
The Bacteriology of HS: A Systematic Review
The bacteriology of hidradenitis suppurativa: a systematic review Synopsis: Included studies in the review A total of 66 papers were identified and nine papers published between 1988 and […]
Apocrine Glands are Bystanders in HS and their Involvement is Gender-Specific
Synopsis: Background: Apocrine glands have been long considered as the initial targeted skin compartment in hidradenitis suppurativa/acne inversa (HS). Objective: Detection of apocrine gland involvement in HS. Methods: […]
Follicular Skin Microbiome
The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls Synopsis: Importance: Although the pathogenesis of hidradenitis suppurativa (HS) remains enigmatic, several factors point to potential involvement […]
Nicastrin Mutation in a Three Generation Dutch Family
A novel nicastrin mutation in a three‐generation Dutch family with hidradenitis suppurativa Synopsis: Background Mutations in the γ-secretase enzyme subunits have been described in multiple kindreds with familial hidradenitis […]
HS Linked Mutations in Four Genes
Analysis of hidradenitis suppurativa-linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages. Synopsis: Hidradenitis suppurativa (HS), or acne inversa, is […]
Role of Androgens & Estrogens
The Role of Androgens and Estrogens in Hidradenitis Suppurativa: A Systematic Review Synopsis: Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a […]
Inflammatory Role of Sex Steroids & Hormones in HS
Inflammatory Role of Sex Steroids in Hidradenitis Suppurativa: An Androgenic Phenotype Synopsis: Abstract: Hidradenitis Suppurativa (HS) is an autoinflammatory skin disease more common in women and associated with hyper-androgenic […]
Defining HS Phenotypes
Defining Hidradenitis Suppurativa Phenotypes Based on the Elementary Lesion Pattern: Results of a Prospective Study Synopsis: Background: It has been proposed that two main phenotypes of hidradenitis suppurativa […]
Skin Transcriptome in HS Uncovers an Antimicrobial
Synopsis: Hidradenitis suppurativa is a chronic and frequently debilitating cutaneous disorder that significantly impacts the quality of life of patients. Compared to other cutaneous disorders, such as psoriasis and atopic […]