Subject: Hormone, Gene & Microbiome

Bacterial biofilm in chronic lesions of hidradenitis suppurativa Synopsis: Background: Chronic nonhealing or recurrent inflammatory lesions, reminiscent of infection but recalcitrant to antibiotic therapy, generally characterize biofilm-driven diseases. Chronic lesions of hidradenitis suppurativa (HS) exhibit several characteristics, which are compatible with well-known biofilm infections. Objectives: To determine and quantify the potential presence of bacterial aggregates […]

The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa Light at the End of the Microbiological Tunnel Synopsis: ​ Hidradenitis suppurativa is a chronic, debilitating inflammatory skin disease whose pathophysiology remains poorly understood [92]. Although the disease itself is relatively uncommon, it is frequently associated with significant physical and psychological morbidity [93] and undoubtedly represents […]

Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa ​ Synopsis: Alterations to key regulatory pathways involving glucocorticoid receptor, atherosclerosis, HIF1α and IL17A signalling as well as inhibition of matrix metalloproteases were detected. From a functional standpoint, cellular assembly, maintenance and movement, haematological system development and function, immune cell […]

The bacteriology of hidradenitis suppurativa: a systematic review ​ Synopsis: ​ Included studies in the review A total of 66 papers were identified and nine papers published between 1988 and 2014 matched the above-mentioned inclusion criteria (Fig. 1), yielding bacteriological data of a total of 324 patients with HS (mean age 36.8 years and female/male […]

Synopsis: ​ Background: Apocrine glands have been long considered as the initial targeted skin compartment in hidradenitis suppurativa/acne inversa (HS). ​ Objective: Detection of apocrine gland involvement in HS. Methods: Apocrine glands were isolated from skin biopsies of involved and uninvolved skin of HS patients (n = 16, females : males 1 : 1) by […]

The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls​ Synopsis: ​ Importance: Although the pathogenesis of hidradenitis suppurativa (HS) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. Insight into the cutaneous microbiome in HS using next-generation sequencing may provide novel data on the microbiological diversity of the skin. […]

A novel nicastrin mutation in a three‐generation Dutch family with hidradenitis suppurativa Synopsis: ​ Background Mutations in the γ-secretase enzyme subunits have been described in multiple kindreds with familial hidradenitis suppurativa (HS). Objective In this study, we report a novel nicastrin (NCSTN) mutation causing HS in a Dutch family. We sought to explore the immunobiological […]

Analysis of hidradenitis suppurativa-linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages. ​ Synopsis: ​ Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin disorder characterized clinically with acne-like lesions in apocrine gland–bearing skin, follicular occlusion and recurrent inflammation. Thirty-four unique mutations in patients with […]

The Role of Androgens and Estrogens in Hidradenitis Suppurativa: A Systematic Review Synopsis: Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. In […]

Inflammatory Role of Sex Steroids in Hidradenitis Suppurativa: An Androgenic Phenotype Synopsis: ​ Abstract: Hidradenitis Suppurativa (HS) is an autoinflammatory skin disease more common in women and associated with hyper-androgenic disorders such as polycystic ovary syndrome. HS is characterized by chronic recurrent deep-seated painful nodules and draining tunnels in skin areas that follow the distribution […]

Defining Hidradenitis Suppurativa Phenotypes Based on the Elementary Lesion Pattern: Results of a Prospective Study ​ Synopsis: ​ Background: It has been proposed that two main phenotypes of hidradenitis suppurativa (HS) exist. This proposal is based upon different elementary structures detected in the skin, namely follicular subtypes and inflammatory subtypes. Having an accurate definition of […]

Synopsis: Hidradenitis suppurativa is a chronic and frequently debilitating cutaneous disorder that significantly impacts the quality of life of patients. Compared to other cutaneous disorders, such as psoriasis and atopic dermatitis, it is relatively poorly characterized. HS is significantly different from these classic inflammatory skin diseases through the clinical presentation of non-healing skin lesions and […]