Subject: Inflammatory, Systemic & Follicle

Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support ​ https://www.ncbi.nlm.nih.gov/m/pubmed/23320858

https://www.jidonline.org/article/S0022-202X(16)31247-7/fulltext

Synopsis: Background: Despite the heavy purulence observed in hidradenitis suppurativa (HS), the kinetics of complement anaphylatoxins acting to prime chemotaxis of neutrophils has not been studied. Objectives: To explore complement […]

Synopsis: A rather long, yet interesting Oxford Article link is below which explains auto-inflammatory disorders and the innate immune. Hidradenitis suppurativa (HS) has long been considered an anatomical disorder of […]

Synopsis: In this review, we collected all the information concerning the OMICs studies performed on HS patients aimed at unraveling the mechanisms at the basis of the disease or associated […]

A total of 32 eligible publications were identified by the systematic search; these were supplemented with three additional publications. The extracted data indicated that four key themes underlie the pathogenesis […]

Synopsis of Research: Etiology Auto-inflammatory Many previously accepted models of HS pathogenesis are being challenged. It is now believed that HS is a systemic inflammatory disease of multifactorial basis, possibly […]

Synopsis: Implicating the immune system in hidradenitis suppurativa The cause of the painful skin condition hidradenitis suppurativa (acne inversa) is unknown. To better understand pathogenesis of this debilitating disease, Byrd […]

Synopsis: In this study, we observed an increased frequency of functional CD4+ T cells secreting IL-17 or IL-22 in the blood of patients with HS compared with healthy donors (HD). […]

Is Mechanical Stress an Important Pathogenic Factor in Hidradenitis Suppurativa?​ Synopsis: In summary, we present a patient with inflammatory lesions, resembling HS, at an ectopic location free of apocrine sweat […]